Brain-wide Functional Connectivity Alterations in Major Depressive Disorder and Baseline Correlates of Treatment Response.

Abstract

BACKGROUND: Major depressive disorder (MDD) has been linked to altered resting-state functional connectivity between the default mode, salience, and task-positive networks. This study aimed to identify resting-state networks with potential utility for distinguishing patients with MDD from healthy controls, and treatment responders from non-responders. METHODS: 108 unmedicated patients with moderate-to-severe MDD (aged 15-25; 67 female) and 100 healthy controls (aged 15-25; 55 female) underwent a 3T-resting-state fMRI scan. Patients were randomized to receive cognitive behavioral therapy for 12 weeks, plus either fluoxetine or placebo. Using whole-brain functional connectivity multivariate pa..